And, well, should they? Perhaps it's inevitable that some seekers of chemical transformation have, over the past few years, begun experimenting with the fate-tempting notion of taking dopamine agonists as a way to achieve the orgasm of the gods. On muscle-building sites such as Testosterone Nation and sex-oriented ones like, it's not uncommon to find debates and amateur advice ("Combine with Cialis for a fun weekend" or "the orgasm was powerful . . . I felt it 'further inside'") regarding the recreational use of cabergoline, a dopamine agonist (usually marketed as Dostinex) that's prescribed in tiny doses to help people with endocrine problems, including high levels of prolactin. Prolactin is the hormone that facilitates breastfeeding when a woman has given birth, but men have the stuff coursing through their veins, too—in fact, prolactin is responsible for the wave of automatic drowsiness that washes over a man seconds after he has ejaculated. Take away the prolactin and, according to some medical trials, a guy's libido can spring right back to life in a matter of seconds. In other words, gentlemen: Meet the male Holy Grail, the possibility of multiple orgasms. Which explains why a dude might be tempted to pop a couple of Dostinex toward the end of a promising date. "Viagra will just increase the blood flow in the penis causing an erection," crows an online ad for under-the-table Dostinex. "Dostinex improves libido, orgasm and ejaculation." Much less is known about the recreational benefits of dopamine agonists like Mirapex and Requip, which are prescribed in higher doses, but clearly they have the power to take an otherwise regular guy like Russ Kelly and make him as rapacious as Tiger Woods. But Kelly's saga also illustrates that there's a downside to turning yourself into a top-gunning, pill-popping Mr. Hyde. "Some people crash," Nirenberg says. "They crash when you try to stop it, and the symptoms are just like when cocaine abusers try to stop. They start having panic attacks—crying and fatigue, they can't get out of bed, they're miserable, they're sweating. It's withdrawal." Sure, doctors concede that there might be something invigorating about a brief lapse into bad behavior, but it can take years to clean up the wreckage. Not long after Russ Kelly's misadventures led to a DUI, he switched to Simenet, which is not a dopamine agonist. He went into therapy to learn how to manage his unleashed cravings and sought counseling to try to repair the damage to his marriage. "These people are not enjoying it," Nirenberg says. Once the Devil has jump-started an endless bender in your brain, it can be very, very hard to kick him out.

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