Don't look now, but the seeds of renewal have long since germinated in the heartland—and the region is booming. Visionary technologists and sustainable-development gurus are reinventing Detroit. Innovative designers, high-end-boutique owners, and restaurateurs are drawing sophisticates to Cleveland. (Yes, that Cleveland.) And today the most artistically progressive enclave in our land isn't Brooklyn, or Portland, or Austin—it's Pittsburgh. Meet the people and organizations driving this American renaissance.